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. 2021 Jul 13;114(1):47–59. doi: 10.1093/jnci/djab133

Table 3.

Self-report measures at baseline (prechemotherapy [A1], post-chemotherapy [A2], and 6 months follow-up [A3]) and changes from pre- to postchemotherapy and changes from prechemotherapy to 6 months follow-up in men and women with lymphoma and age- and sex-paired controls assessed at the same equivalent times

Self-report Outcome Better score Chemotherapy
 Control
 Baseline: chemotherapy (A1) -control (A1)
 Pre- to postchemotherapy: chemotherapy (A2-A1) - control (A2-A1)
 Prechemotherapy to 6 months follow-up: chemotherapy (A3-A1) - control (A3-A1)
A1 A2 A3 A1 A2 A3 Adjusted β (SE) P a Adjusted β (SE) P a Adjusted β (SE) P a
Adjusted mean (SE) Adjusted mean (SE) Adjusted mean (SE) Adjusted mean (SE) Adjusted mean (SE) Adjusted mean (SE) (95% CI) (95% CI) (95% CI)
Women
 FACT-Cog PCI Perceived cognitive impairment Higher 90.72 (3.08)

  • 78.25

  • (3.23)

  • 77.25

  • (3.33)

  • 94.32

  • (3.09)

  • 95.00

  • (3.22)

  • 96.04

  • (3.31)

  • -3.60

  • (2.24)

  • (-7.99 to 0.79)

 .11

  • -13.15

  • (2.04)

  • (-17.16 to -9.15)

 <.001

  • -15.20

  • (2.38)

  • (-19.87 to -10.53)

 <.001
 FACT-Cog total score Perceived cognitive difficulties Higher

  • 148.92

  • (4.81)

  • 129.62

  • (5.36)

  • 129.40

  • (5.66)

  • 158.34

  • (4.39)

  • 158.82

  • (4.41)

  • 159.63

  • (4.43)

  • -9.43

  • (3.37)

  • (-16.04 to -2.81)

 .005

  • -19.77 (3.21)

  • (-26.07 to -13.47)

 <.001

  • -20.80

  • (3.86)

  • (-28.38 to -13.22)

 <.001
 Single item: memory Perceived memory difficulty Higher

  • 2.53

  • (0.34)

  • 3.93

  • (0.37)

  • 3.72

  • (0.36)

  • 2.12

  • (0.34)

  • 2.18

  • (0.37)

  • 2.22

  • (0.36)

  • 0.41

  • (0.25)

  • (-0.08 to 0.90)

 .10

  • 1.34

  • (0.28)

  • (0.78 to 1.89)

 <.001

  • 1.09

  • (0.31)

  • (0.48 to 1.70)

 .002
 Single item: attention Perceived attention difficulty Higher

  • 2.33

  • (0.33)

  • 3.75

  • (0.36)

  • 3.00

  • (0.36)

  • 1.78

  • (0.34)

  • 1.86

  • (0.36)

  • 1.83

  • (0.36)

  • 0.55

  • (0.25)

  • (0.05 to 1.04)

 .03

  • 1.34

  • (0.30)

  • (0.75 1.92)

 <.001

  • 0.63

  • (0.32)

  • (0.01 to 1.25)

 .045
Men
 FACT-Cog PCI Perceived cognitive impairment Higher

  • 91.67

  • (2.87)

 83.23 (2.98)

  • 86.04

  • (3.05)

  • 94.32

  • (2.99)

  • 93.16

  • (3.08)

  • 94.20

  • (3.15)

  • -2.65

  • (1.79)

  • (-6.17 to 0.87)

 .14

  • -7.28

  • (1.64)

  • (-10.50 to -4.06)

 <.001

  • -5.51

  • (1.92)

  • (-9.28 to -1.74)

 .004
 FACT-Cog total score Perceived cognitive difficulties Higher

  • 150.84

  • (4.41)

  • 140.33

  • (4.79)

  • 143.61

  • (4.99)

  • 157.24

  • (4.28)

  • 155.86

  • (4.30)

  • 156.23

  • (4.32)

  • -6.40

  • (2.66)

  • (-11.62 to -1.19)

 .02

  • -9.12

  • (2.51)

  • (-14.06 to -4.19)

 <.001

  • -6.22

  • (3.04)

  • (-12.18 to -0.26)

 .04
 Single item: memory Perceived memory difficulty Higher

  • 2.39

  • (0.31)

  • 3.16

  • (0.34)

  • 2.91

  • (0.33)

  • 2.16

  • (0.33)

  • 2.36

  • (0.35)

  • 2.17

  • (0.34)

  • 0.24

  • (0.20)

  • (-0.16 to 0.63)

 .13

  • 0.56

  • (0.23)

  • (0.11 to 1.01)

 .02

  • 0.50

  • (0.25)

  • (0.01 to 0.99)

 .04
 Single item: attention Perceived attention difficulty Higher

  • 2.08

  • (0.31)

  • 2.70

  • (0.33)

  • 2.39

  • (0.33)

  • 1.77

  • (0.32)

  • 1.92

  • (0.34)

  • 1.90

  • (0.34)

  • 0.31

  • (0.20)

  • (-0.09 to 0.71)

 .21

  • 0.47

  • (0.24)

  • (-0.01 to 0.94)

 .05

  • 0.18

  • (0.26)

  • (-0.32 to 0.69)

 .48
a

Adjusted means, standard errors, 95% confidence intervals (CI), and β estimates are from the longitudinal linear mixed models after adjustment for age, education, race, reading score, baseline anxiety, and baseline depression. Estimates are based on group-by-time-by-sex interaction. All P values are based on 2-sided tests. FACT-Cog = Functional Assessment of Cancer Therapy—Cognitive Function; PCI = perceived cognitive impairment.