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. 2021 Nov 12;41(3):444–458. doi: 10.1038/s41388-021-01903-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Cistrome analysis confirms IFNγ response as one of the top pathways specifically enriched in LN-R273H cell line: GSEA of all genes with TSS within 30 kb of p53 binding peaks specific for LN-R273C and LN-R273H cell lines compared to LN-pLPLUC control. N refers to number of genes enriched in each designated pathway. B Venn diagram shows overlap of genes from IFNγ response pathway specific to distinct mut-p53. C Expression levels of several representative members of IFNγ response pathway, including the genes identified both in cistrome (IFIT1 and ISG15) and transcriptome (CXCL10 and IFIT2) analyses as specific for LN-R273H cells. Two-way ANOVA test was used to determine statistical significance.