Table 3.

Bacterial Genes: Correlation with Cyanobacteria and Enrichment in HCC Cases

Bacterial gene1	Correlation with Cyanobacteria		Enriched in HCC Cases (FDR p <0.0.05)
	r 2	p value	Cases
All-trans-8'-apo-beta-carotenal 15,15'-oxygenase	0.99	<.0001	X
Coenzyme F420 hydrogenase	0.99	<.0001	X
Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase	0.99	<.0001	X
Plastoquinol--plastocyanin reductase	0.99	<.0001	X
Nitric oxide dioxygenase	0.62	<.0001	X
Stearoyl-CoA 9-desaturase	0.57	<.0001
S-(hydroxymethyl)glutathione dehydrogenase	0.36	<.0001
Catalase peroxidase	0.34	<.0001
3-hydroxyisobutyrate dehydrogenase	0.33	<.0001
4-hydroxyphenylpyruvate dioxygenase	0.32	<.0001
Sorbitol-6-phosphate 2-dehydrogenase	0.30	<.0001
3-alpha(or 20-beta)-hydroxysteroid dehydrogenase	0.30	<.0001
Cholesterol oxidase	0.29	0.0001
L-lysine N(6)-monooxygenase (NADPH)	0.28	0.0001	X
Pyrimidine monooxygenase	0.27	0.0002	X
Cyclohexanone monooxygenase	0.26	0.0004	X
Alkanesulfonate monooxygenase	0.25	0.0006
Precorrin-3B synthase	0.25	0.0007
4-hydroxymandelate oxidase	0.25	0.0009	X
Protocatechuate 3,4-dioxygenase	0.24	0.001	X
Decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose 2-reductase	0.24	0.0012
Gluconate 2-dehydrogenase (acceptor)	0.24	0.0012
Alcohol dehydrogenase (azurin)	0.24	0.0012
Decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase	0.23	0.0016
D-galactose 1-dehydrogenase	0.23	0.0016	X
Alcohol dehydrogenase	0.23	0.0023
5,6-dimethylbenzimidazole synthase	0.23	0.0023
Quinoprotein glucose dehydrogenase (PQQ, quinone)	0.23	0.0023	X
4-phosphoerythronate dehydrogenase	−0.23	0.0021

¹90 bacterial genes were significantly correlated with Cyanobacteria; those with r <0.23 or < −0.23 are not shown.

²Spearman correlation