Table 3.
Hallmark Gene Sets Over-represented Among Genes that were Differentially Expressed across OCCC Methylation Cluster 1 and Cluster 2
| Process Category | Description (Gene Set ID) | N (%) | P-value |
|---|---|---|---|
|
| |||
| Immune | Interferon gamma response (17) | 107 (55%) | 1.32 × 10−11 |
| Development | Epithelial mesenchymal transition (6) | 105 (54%) | 1.02 × 10−9 |
| Immune | Allograft rejection (13) | 93 (53%) | 9.66 × 10−9 |
| Immune | Interferon alpha response (16) | 55 (57%) | 1.80 × 10−7 |
| Immune | Inflammation (19) | 88 (47%) | 1.59 × 10−5 |
| Immune | Complement cascade (15) | 85 (46%) | 7.53 × 10−5 |
| Signaling | KRAS signaling, downregulated genes (43) | 82 (44%) | 6.08 × 10−4 |
| DNA damage | UV response: downregulated genes (11) | 63 (44%) | 7.91 × 10−3 |
| Immune | IL6 STAT3 signaling during acute phase response (18) | 37 (46%) | 6.10 × 10−3 |
P<10−2; N (%) represent number of genes differentially expressed by OCCC methylation Cluster 1 v Cluster 2 and % of genes in each overall gene set.