Skip to main content
. Author manuscript; available in PMC: 2023 Jan 15.
Published in final edited form as: J Immunol. 2021 Dec 29;208(2):407–419. doi: 10.4049/jimmunol.2100029

Figure 5. Vaccination enhances expression of Tnfsf8 (CD153) in parenchyma-homing T cells and in the CD4 T cell compartment.

Figure 5.

Mice were vaccinated three times at 4 week intervals with intranasal H1/CDN. (a) scRNA-seq results from all CXCR3+KLRG1− vs. CXCR3−KLRG1+ CD4 T cells were compared. Top genes that were differentially expressed in these subtypes. (b) Flow cytometry analysis for CD153 expression on CD4 T cells at day 0 prior to challenge or (c) at 4 weeks post challenge. (d) Network analysis of scRNA-seq results comparing CXCR3+KLRG1− and CXCR3−KLRG1+. Orange nodes are overrepresented in CXCR3+ cells; blue nodes are overrepresented in KLRG1+ cells.