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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Pharmacol Res. 2021 Nov 24;175:105998. doi: 10.1016/j.phrs.2021.105998

Fig. 2. The combination of berberine and osimertinib augments induction of apoptosis in MET-amplified osimertinib-resistant cells.

Fig. 2.

The indicated cell lines were treated with DMSO, 200 nM osimertinib (Osim), 100 μM berberine (BBR) or their combination (Comb) for 48 h. Apoptosis was detected with Western blotting for protein cleavage (A) and with flow cytometry for annexin V-positive cells (B). Data in each group are means ± SDs of duplicate determinations.