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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: Pharmacol Res. 2021 Nov 24;175:105998. doi: 10.1016/j.phrs.2021.105998

Fig. 5. Berberine and osimertinib combination enhances suppression of MET and its downstream signaling in MET-amplified osimertinib-resistant cells (A), which are relatively more sensitive to berberine (B).

Fig. 5.

A, HCC827/AR cells were treated with DMSO, 200 nM osimertinib (Osim), 100 μM berberine (BBR) or their combination for varied times as indicated, then harvested for preparation of whole-cell protein lysates and subsequent Western blotting to detect the indicated proteins. B, The indicated cell lines seeded in 96-well plates were exposed to varied concentrations of berberine for 72 h. Cell numbers were determined with the SRB assay. The data are means ± SDs of four replicate determinations.