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. 2022 Jan 4;18:1–10. doi: 10.2147/NDT.S338489

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© 2022 Ji et al.

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Brain regions showing changes in functional connectivity (FC) values in the PI group, compared with the HC group. Seed points are marked in red, and the brain regions displaying differences in FC are marked in blue. The decreased FC was displayed as gray edge, and increased FC was displayed as green edge. The functional connections between the seed points and the different brain regions are displayed as gray lines (FC, PI < HC; P < 0.005, 3dClusSim correction). Left figure: whole-brain FC analysis with the left medial frontal gyrus as the seed point, PI patients displayed decreased FC between the left medial prefrontal cortex and the left fusiform gyrus compared with HCs. Right figure: whole-brain FC analysis with the left supplementary motor area as the seed point, PI patients exhibited increased FC between the left supplementary motor area and the right anterior cingulum cortex.