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. 2022 Jan 12;8:21. doi: 10.1038/s41420-021-00798-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A TPC-1 and B-CPAP cells were transfected with circTIAM1 short hairpin RNAs or overexpression plasmid, and the expression levels of circTIAM1 and TIAM1 mRNA were measured by RT-qPCR and normalized to GADPH level. B The effect of circTIAM1 downregulation or overexpression on cell migration was evaluated by the Transwell migration assay in PTC cells. Scale bar = 100 μm. C The wound-healing assay was conducted to evaluate the migration abilities of TPC cells transfected with sh-circTIAM1/ex-circTIAM1 plasmid or vector. D Representative images of PTC cells transfected with sh-circTIAM1 or ex-circTIAM1 in colony formation assay. E Cell proliferation rate was significantly suppressed in PTC cells with circTIAM1 knockdown, while it was increased with circTIAM1 overexpression. F PTC cells were transfected with sh-circTIAM1, and Annexin V-FITC/PI staining was conducted to show the percentage of apoptotic cells. Data represent the mean ± SD. Three independent assays were performed (A–F) (*p < 0.05; Student’s t-test).