Table 4.
Association between nuclear MAGE-A6 (A6)/MAGE-A11 (A11) phenotypes and clinicopathological parameters in BC cases (P‐value, Pearson's chi‐square test).
| Tumour characteristic | Phenotypes of Nuclear MAGE-A6/MAGE-A11 expression, N (%) | ||||
|---|---|---|---|---|---|
| A6l/A11l | A6h/A11l | A6l/A11h | A6h/A11h | P-value | |
|
Median age Years | |||||
| ≤ 65 | 28 (57.1) | 24 (35.8) | 11 (52.4) | 10 (47.6) | 0.133 |
| > 65 | 21 (42.9) | 43 (64.2) | 10 (47.6) | 11 (52.4) | |
| Gender | |||||
| Male | 37 (75.5) | 52 (77.6) | 16 (76.2) | 18 (85.7) | 0.815 |
| Female | 12 (24.5) | 15 (22.4) | 5 (23.8) | 3 (14.3) | |
| Mean tumor size (cm) | 0.007 | ||||
| ≤ 2.5 | 37 (75.5) | 41 (61.2) | 15 (28.6) | 7 (33.3) | |
| > 2.5 | 12 (24.5) | 26 (38.8) | 6 (28.6) | 14 (66.7) | |
| Histological grade | < 0.0001 | ||||
| Low | 35 (71.4) | 11 (16.4) | 13 (61.9) | 3 (14.3) | |
| High | 14 (28.6) | 56 (83.6) | 8 (38.1) | 18 (85.7) | |
| pT stage | |||||
| pTa | 30 (61.2) | 16 (24) | 11 (52.4) | 3 (14.3) | < 0.0001 |
| pT1 | 13 (26.5) | 36 (53.6) | 8 (38.1) | 13 (61.9) | |
| pT2 | 6 (12.2) | 15 (22.4) | 2 (9.5) | 5 (23.8) | |
| pT3 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
| pT4 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
| Lamina propria involvement | < 0.0001 | ||||
| Involved | 19 (38.8) | 51 (76.1) | 10 (47.5) | 18 (85.7) | |
| None | 30 (61.2) | 16 (23.9) | 11 (52.4) | 3 (14.3) | |
| Muscularis invasion | 0.319 | ||||
| Involved | 6 (12.2) | 15 (22.4) | 2 (9.5) | 5 (23.8) | |
| None | 43 (87.8) | 52 (77.6) | 19 (90.5) | 16 (76.2) | |
| Lamina propria/muscularis involvement (L/M) | < 0.0001 | ||||
| L − /M- | 30 (61.2) | 16 (23.9) | 11 (52.4) | 3 (14.3) | |
| L + /M- | 13 (26.5) | 36 (53.7) | 8 (38.1) | 13 (61.9) | |
| L + /M + | 6 (12.2) | 15 (22.4) | 2 (9.5) | 5 (23.8) | |
| Recurrence | 0.349 | ||||
| Present | 13 (26.5) | 23 (34.3) | 6 (28.6) | 3 (14.3) | |
| Absent | 36 (73.5) | 44 (65.7) | 15 (71.4) | 18 (85.7) | |
| Distant metastasis | 0.352 | ||||
| Present | 8 (16.3) | 13 (19.4) | 1 (4.8) | 2 (9.5) | |
| Absent | 41 (83.7) | 54 (80.6) | 20 (95.2) | 19 (90.5) | |
Bold numbers represent significant p-values.
h: high expression, l: low expression.