. 2022 Jan 12;12:599. doi: 10.1038/s41598-021-04510-2

Table 5.

Association between cytoplasmic MAGE-A6 (A6)/MAGE-A11 (A11) phenotypes and clinicopathological parameters in BC cases (P‐value, Pearson's chi‐square test).

Tumour characteristic	Phenotypes of cytoplasmic MAGE-A6/MAGE-A11 expression, N (%)
Tumour characteristic	A6^l/A11^l	A6^h/A11^l	A6^l/A11^h	A6^h/A11^h	P-value
Median age
Years (range)
65 ≤	11 (47.8)	18 (47.4)	12 (54.5)	32 (42.7)	0.792
65 >	12 (52.2)	20 (52.6)	10 (45.5)	43 (57.3)	0.792
Gender
Male	18 (78.3)	30 (78.9)	15 (68.2)	60 (80)	0.7
Female	5 (21.7)	8 (21.1)	7 (31.8)	15 (20)	0.7
Tumor size (cm)
2.5 ≤ Mean	20 (87)	24 (63.2)	15 (68.2)	41 (54.7)	0.043
2.5 > Mean	30 (13)	14 (36.8)	7 (31.8)	34 (45.3)	0.043
Histological grade
Low	17 (73.9)	19 (50)	12 (54.5)	14 (18.7)	< 0.0001
High	6 (26.1)	19 (50)	10 (45.5)	61 (81.3)	< 0.0001
pT stage
pTa	16 (69.6)	18 (47.4)	11 (50)	15 (20)	< 0.0001
pT1	5 (21.7)	11 (28.9)	9 (41)	45 (60)
pT2	2 (8.7)	9 (23.7)	2 (9)	15 (20)
pT3	0 (0)	0 (0)	0 (0)	0 (0)
pT4	0 (0)	0 (0)	0 (0)	0 (0)
Lamina propria involvement
Involved	7 (30.4)	20 (52.6)	11 (50)	60 (80)	< 0.0001
None	16 (69.6)	18 (47.4)	11 (50)	15 (20)	< 0.0001
Muscularis invasion					0.308
Involved	2 (8.7)	9 (23.7)	2 (9.1)	15 (20)
None	21 (91.3)	29 (76.3)	20 (90.9)	60 (80)
Lamina propria/muscularis involvement (L/M)					< 0.0001
L − /M-	16 (69.6)	18 (47.4)	11 (50)	15 (20)
L + /M-	5 (21.7)	11 (28.9)	9 (40.9)	40 (60)
L + /M +	2 (8.7)	9 (23.7)	2 (9.1)	15 (20)
Recurrence
Present	4 (17.4)	10 (26.3)	9 (40.9)	22 (29.3)	0.366
Absent	19 (82.6)	28 (73.7)	13 (59.1)	53 (70.7)	0.366
Distant metastasis
Present	2 (8.7)	6 (15.8)	4 (18.2)	12 (16)	0.812
Absent	21 (91.3)	32 (84.2)	18 (81.8)	63n	0.812

Bold numbers represent significant p-values.

h: high expression, l: low expression.