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. 2022 Jan 12;7:3. doi: 10.1038/s41536-021-00196-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Immunohistochemistry of Shh expression in A control and B LysMCre/SmoKO mouse stomachs. Shh expression at the ulcer margin of C, D control, and E, F LysMCre/SmoKO mouse stomachs. G Shh concentrations (pg/mL) measured in plasma collected from in control and LysMCre/SmoKO mice. Macrophage numbers (CD11b⁺F4/80⁺Ly6C^hi) within the uninjured and injured gastric epithelium of H control and I LysMCre/SmoKO mice 1–7 post-ulcer induction. *P < 0.05 compared to day 1 post-injury, n = 6 mice per group. Data are shown as the mean ± SEM.