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. 2022 Jan 12;7:3. doi: 10.1038/s41536-021-00196-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A Expression of Shh in EpCAM fractions isolated from vehicle (Veh, 1), vismodegib (Vis, 2), Histamine (Hist, 3), or Vis+Hist (4) treated co-cultures. B Expression of Ptch1 in MΦ fractions isolated from Veh, Vis, Hist, or Vis+Hist treated co-cultures. C Expression of M1 and M2 markers in MΦ fractions isolated from Veh, Vis, Hist, or Vis+Hist treated co-cultures. D Expression of CCR2 in MΦ fractions isolated from Veh, Vis, Hist, or Vis+Hist treated co-cultures. E Protein expression of AKT and pAKT in MΦ fractions isolated from Veh, Vis, Hist, or Vis+Hist treated co-cultures. Quantification of immunoblots in E is shown in (F). G Schematic diagram showing Shh-induced macrophage migration that is Smo-dependent is mediated by AKT signaling. *P < 0.05 compared to vehicle. Data are shown as the mean ± SEM.