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. 2022 Jan 12;13:290. doi: 10.1038/s41467-021-27915-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A–C Three views: side view (A), cytosolic view (B), and extracellular view (C) of the cryo-EM structure of the prestin dimer. The prestin structure is colored by the subunit in cyan and yellow, respectively. D–F Atomic model based on the cryo-EM density, shown in the same orientations as the density maps in the panels (A–C). The N terminus and C terminus of the prestin structure face the cytosol. The different domain structures of prestin are colored using the same color scheme as shown in the schematic representation of the prestin sequence (G). (H, I) Two close-up views, rotated ~45° with respect to each other, showing a density segment of the IVS loop overlaid with the model (shown in green ribbon) within the STAS-domain structure (shown in surface representation, in orange). Panels (H, I) show enlarged views of the interface boxed in panel (D). The positions of residues (R571, K580, and E637) from the IVS loop (shown in green ribbon) are indicated. Residue A726 is labeled to highlight the C terminus of the structure.