Figure 3.

Association of innate immunity-related markers with severity. (A) Hierarchical clustering of the correlation matrix from phenotypic and soluble markers significantly correlated with SAPS II score or the PaO₂/FiO₂ ratio in ICU patients. Red is for positive correlation and green for negative correlation. Intensity of color is proportional to Spearman correlation coefficient. Cluster A groups markers with a correlation profile similar to SAPS II score. Cluster B groups markers with correlation profiles similar with PaO₂/FiO₂ ratio. (B) Markers significantly different between patient who survived (red) or died (black) during their ICU stay. The histograms represent the median and the error bars the interquartile range. Intergroup comparison by Mann–Whitney U test between survivors and deceased patients, **P < 0.01, *P < 0.05. (C) Hierarchical clustering of the correlation matrix from phenotypic and soluble markers significantly correlated with external oxygen requirement on the day of sampling (O₂), maximal external oxygen requirement (Max_O2) or length of hospitalization in non-ICU patients (stay_lengh). Red is for positive correlation and green for negative correlation. Intensity of color is proportional to Spearman correlation coefficient. Cluster A groups markers with a correlation profile similar to O2, Max_O2 and stay_length. Cluster B groups markers negatively correlated to cluster A. BC_PN: neutrophil absolute count; BC_Mono: monocyte absolute count. Hierarchical clustering was made with Genesis 1.8.1 (Gratz University of Technology, https://genome.tugraz.at/genesisclient/genesisclient_description.shtml).