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. 2022 Jan 12;12:633. doi: 10.1038/s41598-021-04600-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Adult hippocampal neurogenesis is not altered in Syn-Dagla KO mice. (A) Representative immunohistochemistry stainings of Syn-Dagla KO and control mice. Syn-Dagla KO mice show similar number of BrdU-positive cells (red) 1 day after the last injection. 21 days after BrdU injections, the number of BrdU positive cells does not differ between Syn-Dagla KO mice and controls. Additionally, brains were stained with an astrocytic marker GFAP (yellow) and a neuronal marker NeuN (green) to investigate differentiation, which was unchanged (scale bar: 100 µm). (B) The number of BrdU-positive cells in dentate gyrus of Syn-Dagla KO mice was similar to controls, one and 21 days after BrdU injections. (C) Differentiation of progenitor cells in dentate gyrus of Syn-Dagla KO mice. BrdU-positive cells were analyzed for co-expression of neuronal marker NeuN and astrocytic markers GFAP and S100beta. Values represent mean ± SEM; n = 4 animals/group, 6 analyzed pictures/animal. Student’s t-test.