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. 2022 Jan 12;12:633. doi: 10.1038/s41598-021-04600-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Daglb expression is downregulated in GLAST-CreERT2-Dagla KO mice. Representative 40 × images of an RNAscope in situ hybridisation assay detecting transcripts of diacylglycerol lipase beta Daglb (red) and neural progenitor marker Sox 2 (white) in the dentate gyrus of hippocampus (DG) (scale bar 50 µm) (A) in Dagla fl/fl control mice, (B) in GLAST-CreERT2-Dagla KO with a deletion in astrocytes and neuronal progenitor cells, (C) in constitutive neuronal Syn-Dagla KO animals, and (D) in total Dagla KO mice. Quantification of Daglb particle count at Bregma − 1.70 mm (E) in the whole hippocampal DG region (including the granule cell layer, the hilus/polymorph layer of DG, and the molecular layer of DG) (F_3,22 = 7.522, p = 0.0012) and (F) only in the granule cell layer that consists mostly of neurons (F_3,22 = 7.256, p = 0.0015). Values represent mean ± SEM; n = 2–4 animals/group; 2 pictures analyzed per animal. 1-way ANOVA with Dunnett’s multiple comparisons test.