Table 1.

Associations between PRSs and autism-related phenotypes at GWAS p-value threshold 0.05, adjusted for 10 genetic principal components.

	Rheumatoid arthritis PRS for mothers			Rheumatoid arthritis PRS for offspring
Outcome	N	RR (95% CIs)	P	N	RR (95% CIs)	P
Autism cases	7685	0.89 (0.73–1.07)	0.21	7849	1.11 (0.88–1.39)	0.39
SCDC	5071	0.98 (0.90–1.07)	0.95	5450	1.02 (0.94–1.10)	0.67
Coherence	4992	0.95 (0.87–1.03)	0.21	5568	1.01 (0.94–1.09)	0.76
Repetitive behaviour	5249	0.96 (0.86–1.06)	0.40	5557	1.06 (0.97–1.17)	0.21
Sociability	5965	0.96 (0.89–1.03)	0.27	6176	0.99 (0.92–1.06)	0.75

PRSs polygenic risk scores, GWAS genome-wide association study, N sample size in analysis, RR relative risk, (95% CIs) 95% confidence intervals, P p-value, SCDC social communication difficulties as measured by the Social Communications Disorder Checklist.