Table 2.
MR analysis results assessing causal effects of rheumatoid arthritis on autism, and juvenile idiopathic arthritis on autism.
| Exposure and outcome | Method | No. of SNPs | OR (95% CI) | p-value |
|---|---|---|---|---|
| Rheumatoid arthritis and autism | ||||
| IVW | 40 | 1.01 (0.98, 1.04) | 0.56 | |
| MR-Egger | 40 | 1.01 (0.97, 1.05) | 0.72 | |
| Weighted median | 40 | 1.00 (0.96, 1.04) | 0.92 | |
| Juvenile idiopathic arthritis and autism | ||||
| IVW | 6 | 1.00 (0.98, 1.02) | 0.99 | |
| MR-Egger | 6 | 1.02 (0.96, 1.08) | 0.58 | |
| Weighted median | 6 | 1.00 (0.98, 1.03) | 0.56 | |
SNPs single nucleotide polymorphisms, OR odds ratio, (95% CIs) 95% confidence intervals, IVW inverse variance weighted method, MR-Egger Mendelian randomization Egger method.