Fig. 1. Schematic of ImmTOR mechanism of action. ImmTOR is selectively taken up by antigen-presenting cells, such as dendritic cells (DC) in the spleen and liver.

ImmTOR induces tolerogenic DCs that process and present co-administered antigen in a manner that results in the expansion of antigen-specific regulatory T cells. The Tregs inhibit activation of effector T cells and prevent the formation of anti-drug antibodies. Adapted from Kishimoto⁸.