Table 2.
List of S. cerevisiae ‘omics datasets with a brief description of methodology. A total of two studies include C. glabrata datasets. (Abbreviations: 5-FC, 5-flucytosine; FCZ, fluconazole; MCN, miconazole; CTZ, clotrimazole; KCZ, ketoconazole; ICZ, itraconazole; CSP, caspofungin and AmB, amphotericin B.)
| Citation | Species | Analysis | Strain | Drug | Methods details |
|---|---|---|---|---|---|
| Zhang et al. (2002) | S. cerevisiae | Transcriptomics (Microarray) | L1190 | 5-FC, 25 µg/mL | OD600 ∼0.8, 30°C YPD, exposed to 5-FC for 90 min, n = 1 |
| (0.5x MIC100) | |||||
| Agarwal et al. (2003) | S. cerevisiae | Transcriptomics (Microarray) | S288c | AmB, 0.12 µg/mL | OD600 ∼0.2, 30°C, SD, exposed to drug for 3 h, n = 2 |
| 5-FC, 0.3 µg/mL | |||||
| CSP, 0.02 µg/mL | |||||
| KCZ, 56 µg/mL | |||||
| Reinoso-Martin et al. (2003) | S. cerevisiae | Transcriptomics (Microarray) | BY4741 | CSP, 10 ng/mL | OD600 ∼1, 30°C YPD, exposed to CSP for 1, 2 and 3 h, n = 4 |
| Kuo et al. (2010) | S. cerevisiae, | Transcriptomics (Microarray) | BY4741 | FCZ, 4 µg/mL (MIC50) | OD600 ∼0.05–0.2, 30°C YPD, cells |
| C. glabrata | CBS138 | harvested 0, 1/3, 2/3, 1, 2 or 4 doubling times, n = 3 | |||
| Nishikawa et al. (2016) | S. cerevisiae, | Transcriptomics (RNA-Seq) | BY4741 | KCZ, 40 µM | OD600 ∼0.8, 30°C YPD, treated with DMSO 8 h, then KCZ for 15 min; n = 3 |
| C. glabrata | DSY562 | ||||
| Pang et al. (2017) | S. cerevisiae | Transcriptomics (RNA-Seq) | S288c | AmB, 0.03 µg/mL | 30°C RPMI-1640, 50–60 min drug treatment; n = 3 |
| Garcia et al. (2017) | S. cerevisiae | Transcriptomics (Microarray) | BY4741 | CSP, 15 ng/mL | OD600 ∼0.2, 30°C YPD, 2 h drug treatment; n = 3 |
| ATripathi et al. (2020) | S. cerevisiae | Transcriptomics (RNA-Seq) | S288c | CSP, 0.03 µg/mL | OD600 ∼0.1, 30°C SD +/− drug for ∼4 h, n = 3 |
| Messner et al. (2021) | S. cerevisiae | Proteomics (ScanningSWATH) | BY4741 | MCN, KCZ, ICZ and CTZ, 10 µM | Overnight 30°C SD transferred to 96-well plate, exposed to drug overnight; n = 3–4 |