Table 3.
List of C. glabrata antifungal ‘omics datasets with a brief description of methodology. (Abbreviations: 5-FC, 5-flucytosine; FCZ, fluconazole; CTZ, clotrimazole; KCZ, ketoconazole and AmB, amphotericin B.)
| Citation | Species | Analysis | Strain | Drug | Methods details |
|---|---|---|---|---|---|
| Caudle (unpublished data) | C. glabrata | Transcriptomics (Microarray) | 200989 | FCZ, 64 µg/mL | OD600 ∼0.2, 30°C YPD, +/− drug 2.5 h, n = 3 |
| 2x MIC | |||||
| Kuo et al. (2010) | S. cerevisiae, | Transcriptomics (Microarray) | BY4741 | FCZ, 4 µg/mL | OD600 ∼0.05–0.2, 30°C YPD, cells |
| C. glabrata | CBS138 | MIC50 | Harvested 0, 1/3, 2/3, 1, 2 or 4 doubling times, n = 3 (2x technical) | ||
| Nishikawa et al. (2016) | S. cerevisiae, | Transcriptomics (RNA-Seq) | BY4741 | KCZ, 40 µM | OD600 ∼0.8, 30°C YPD, treated with DMSO 8 h, then KCZ for 15 min; n = 3 |
| C. glabrata | DSY562 | ||||
| Pais et al. (2020) | C. glabrata | Transcriptomics (RNA-Seq) | KUE100 | FCZ, 150 µg/mL | 30°C basal medium to mid-exponential phase, treated +/− drug 1 h, n = 3 (2x technical) |
| Alves et al. (2020) | C. glabrata | Transcriptomics (RNA-Seq) | CBS138 | FCZ, 1250 µg/mL | Pre-formed biofilms +/− drug at 37°C in RPMI pH 7.0, 24 h, n = 3 |
| Pais et al. (2016a) | C. glabrata | Proteomics (iTRAQ-MS) | 66032 | 5-FC, 4 µg/mL | 30ºC Basal medium, +/− 5-FC 1 h, n = 3 |
| Pais et al. (2016b) | C. glabrata | Proteomics (iTRAQ-MS) | 66032 | CTZ, 100 µg/mL | OD600 ∼0.4, 30°C basal medium, 1 h, n = 3 |