Table 1.
Morphological and biochemical measures of non-diabetic and diabetic mice treated with vehicle or GIP.
| Non-DM | DM-vehicle | DM-GIP | |
|---|---|---|---|
| Number | 6 | 6 | 6 |
| Food intake (g/day) | 4.0 ± 0.0 | 7.1 ± 1.2 ** | 7.4 ± 1.7 ** |
| Final body weight (g) | 25.7 ± 0.4 | 41.3 ± 1.9 ** | 41.7 ± 2.2 ** |
| Heart index | 6.1 ± 0.3 | 7.2 ± 0.7 ** | 7.4 ± 0.4 ** |
| Pulse rate (/min) | 528 ± 27 | 557 ± 26 | 539 ± 58 |
| Systolic blood pressure BP (mmHg) | 106 ± 27 | 140 ± 17 * | 130 ± 17 * |
| Diastolic blood pressure (mmHg) | 71 ± 27 | 108 ± 16 * | 105 ± 18 * |
| HbA1c (%) | <4.0 | 11.7 ± 0.3 ** | 11.5±0.5 ** |
| Plasma glucose (mg/dL) | 113 ± 21 | 590 ± 81 ** | 560 ± 80 ** |
| Plasma insulin (ng/mL) | 0.48 ± 0.27 | 0.37 ± 0.21 | 0.24 ± 0.10 |
| Plasma total cholesterol (mg/dL) | 68 ± 6 | 92 ± 10 ** | 86 ± 9 ** |
| Plasma triglycerides (mg/dL) | 115 ± 7 | 151 ± 43 | 119 ± 28 |
| Plasma total GIP (pg/mL) | 2.7 ± 2.2 | 1.5 ± 1.5 | 6.8 ± 4.6 † |
Mean ± SD. * and **, p < 0.05 and p < 0.01 versus Non-DM, respectively.
†
p < 0.05 versus DM-vehicle. HbA1c levels in non-DM mice were below the detectable limit of assay used, and their values were rounded up to 4.0 for statistical comparisons.