Table 4.
Vital Signs Pharmacodynamics Parameters’ Statistical Analysis
| Outcomes | A | A/RB | RB | P | Parameter | ES (95% CI) |
ES (95% CI) |
Interaction |
|---|---|---|---|---|---|---|---|---|
| Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Alcohol | RB | |||
| SBP | 5.06 ± 16.61 | 9.25 ± 13.69 | 7.50 ± 11.56 | −0.56 ± 11.57 | Peak | 5.6 (−3.1 to 14.4) N.S. | 8.1(−0.7 to 16.8) N.S. | N.S. |
| mmHg | −8.94 ± 46.98 | 16.53 ± 50.70 | 18.20 ± 44.57 | −8.13 ± 36.83 | AUC0-8h | −0.8 (29.0 to 27.3) N.S. | 26.3 (−1.8 to 54.5) N.S. | N.S. |
| DBP | −6.31 ± 12.86 | −0.75 ± 14.72 | 7.13 ± 9.18 | −1.00 ± 10.66 | Peak | −5.3 (−12.8 to 2.2) N.S. | 8.1 (0.6 to 15.6)* | N.S. |
| mmHg | −36.72 ± 48.46 | −13.05 ± 51.88 | 17.42 ± 33.75 | −14.92 ± 35.84 | AUC0-8h | −21.8 (−48.1 to 4.6) N.S. | 32.3 (6.0 to 58.7)* | N.S. |
| Heart rate | 15.06 ± 11.13 | 11.75 ± 12.21 | 0.38 ± 10.51 | 4.38 ± 13.51 | Peak | 10.7 (3.1 to 18.3)** | −4.0 (−11.6 to 3.6) N.S. | N.S. |
| bpm | 58.34 ± 45.45 | 53.13 ± 63.88 | −6.58 ± 37.09 | 6.48 ± 52.05 | AUC0-8h | 51.9 (17.5 to 86.2)** | −13.1 (−47.5 to 21.3) N.S. | N.S. |
| Temperature | −0.34 ± 0.49 | 0.03 ± 0.64 | 0.02 ± 0.72 | −0.33 ± 0.55 | Peak | −0.0 (−0.4 to 0.4) N.S. | 0.4 (−0.0 to 0.7) N.S. | N.S. |
| ºC | −0.83 ± 1.66 | 0.51 ± 1.99 | 0.88 ± 2.56 | −0.84 ± 2.15 | AUC0-8h | 0.0 (−1.4 to 1.5) N.S. | 1.7 (0.3 to 3.2)* | N.S. |
Abbreviations: A, alcohol + placebo Red Bull; A/RB, alcohol + Red Bull; AUC, area under the curve; CI, confidence interval; DBP, diastolic blood pressure; ES, estimated substance effect; P, placebo alcohol + placebo Red Bull; RB, Red Bull+ placebo alcohol; SBP, systolic blood pressure. N.S, not significant, * P < .05; ** P < .01; *** P < .001.