Fig. 2.

Treatment response of patients treated with radiotherapy according to mutational status. (A) A waterfall plot of the percentage changes in radiotherapy-treated lesions compared to measurements in pre-radiotherapy lesions. The bottom panel represents the primary tumor site, radiotherapy (RT) site, radiotherapy dose (EQD2), best response (BR), and mutation status of ATM, BRCA1, BRCA2, TP53, and PALB2. The line at 20% and −30% indicate the threshold for progressive disease and objective response per Response Evaluation Criteria in Solid Tumors (RECIST) ver. 1.1. Two patients with partial response (PR) per RECIST exhibited a complete metabolic response according to Positron Emission Tomography Response Criteria in Solid Tumors. CR, complete response; CUP, cancer of unknown primary; GI, gastrointestinal; GYN, gynecologic; PD, progression of disease; SD, stable disease. (B) A swimmer plot representing the duration of response of patients who exhibited an objective response. Arrows indicate an ongoing response at the time of data censoring.