Table 4.
Characteristics of the patients with grade 5 toxicities
| Patient No. | Age (yr)/Sex | Histology | iStage | iRT | rStage | Re-RT | DFI (mo) | TFS (mo) | OS (mo) | Disease status | Cause of death | Combined toxicities |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 28/male | NK | iT4N2 | 3D 72 Gy/40 fractions CCRT |
rT4N1 | 3D 60 Gy/24 fractions RT alone |
6 | 4 | 53 | Local re-recurrence 3rd re-RT | Brain necrosis | - |
| 2 | 53/female | K | iT4N1 | IMRT 68.4 Gy/30 fractions CCRT |
rT4N0 | IMRT 60 Gy/20 fractions RT alone |
9 | 7 | 21 | NED | Mucosal necrosis with bleeding | Brain necrosis |
| 3 | 57/male | NK | iT4N2 | 2D 75.4 Gy/42 fractions CCRT |
rT3N0 | 3D 54 Gy/18 fractions RT alone |
36 | 2 | 7 | NED | Brain necrosis | - |
| 4 | 40/female | NK | iT3N1 | 2D 64.8 Gy/36 fractions RT |
rT2N0 | 3D 62.5 Gy/25 fractions RT alone |
33 | 7 | 12 | NED | Brain necrosis | - |
| 5 | 52/male | NK | iT4N2 | IMRT 70 Gy/35 fractions CCRT |
rT1N1 | IMRT 60 Gy/20 fractions RT alone |
27 | 13 | 16 | NED | Mucosal necrosis with bleeding | - |
| 6 | 50/male | NK | iT1N2 | 3D 70 Gy/35 fractions CCRT |
rT1N0 | IMRT 60 Gy/20 fractions RT alone |
39 | 5 | 13 | NED | Mucosal necrosis with bleeding | - |
| 7 | 69/male | NK | iT2N2 | 3D 72 Gy/40 fractions IC+CCRT |
rT1N1 | IMRT 54 Gy/18 fractions RT alone |
109 | 9 | 18 | NED | Mucosal necrosis with bleeding | Osteo-necrosis |
Lower case letters “i” and “r” in front of a word represent initial RT and re-RT, respectively. CCRT, concurrent chemoradiation therapy; DFI, disease-free interval; IC, induction chemotherapy; IMRT, intensity-modulated radiation therapy; K, keratinizing squamous cell carcinoma; NED, no evidence of disease; NK, non-keratinizing carcinoma; OS, overall survival; RT, radiation therapy; TFS, toxicity-free survival.