Fig. 5.

Genetic and histological landscape of glioblastomas. We excluded variants which had been reported as benign or likely benign in ClinVar (https://www.ncbi.nlm.nih.gov/clinvar/). CDK4, cyclin-dependent kinase 4; CDKN2A/B, cyclin-dependent kinase inhibitor 2A/B; EGFR, epidermal growth factor receptor; FGFR3, fibroblast growth factor receptor 3; IDH1/2, isocitrate dehydrogenase 1/2; MGMT, O-6-methylguanine-DNA-methyltransferase; NF1, neurofibromin 1; NGS, next-generation sequencing; PDGFRA, platelet-derived growth factor receptor A; PI3K, phosphoinositide 3-kinase; RB, retinoblastoma; RTK, receptor tyrosine kinase; TERT, telomerase reverse transcriptase.