Table 2. Cancer-specific mortality, overall mortality, BCR, metastatic disease, and hospital readmissions by stage and treatment group.
Variable | Locally advanced disease | Clinically localized disease | |||||
---|---|---|---|---|---|---|---|
Surgery (n=54) | Radiotherapy (n=35) | p-value | Surgery (n=66) | Radiotherapy (n=142) | p-value | ||
Cancer-specific mortality | 0.082 | 0.597 | |||||
Total person-years in follow-up | 254 | 168 | 344 | 768 | |||
Number of deaths due to prostate cancer | 0 | 2 | 1 | 4 | |||
Prostate cancer deaths per 1,000 person-years | 0.0 (0.0–14.4) | 11.9 (1.3–43.0) | 2.9 (0.0–16.2) | 5.2 (1.4–13.3) | |||
Overall mortality | 0.003 | 0.019 | |||||
Total person-years in follow-up | 254 | 168 | 344 | 768 | |||
Number of deaths due to any cause | 1 | 8 | 4 | 29 | |||
All-cause deaths per 1,000 person-years | 3.9 (0.1–21.9) | 47.6 (20.5–93.8) | 11.6 (3.1–29.8) | 37.8 (25.3–54.2) | |||
Incidence of BCR | <0.001 | 0.897 | |||||
Person-years in follow-up free of BCR | 155 | 150 | 297 | 699 | |||
Number of men with BCR | 32 | 7 | 12 | 27 | |||
BCR per 1,000 person-years | 207.0 (141.0–292.0) | 46.7 (18.7–96.2) | 40.4 (20.9–70.6) | 38.6 (25.5–56.2) | |||
Incidence of metastatic disease | 0.275 | 0.409 | |||||
Person-years in follow-up free of metastatic disease | 240 | 154 | 338 | 744 | |||
Number of men with metastatic disease | 6 | 7 | 4 | 14 | |||
Metastatic disease per 1,000 person-years | 25.0 (9.1–54.4) | 45.5 (18.2–93.7) | 11.8 (3.2–30.3) | 18.8 (10.3–31.6) | |||
Incidence of hospital readmissions | 0.002 | 0.044 | |||||
Number of men with hospital readmissions | 10 | 17 | 13 | 50 | |||
Proportion of men with readmissions | 18.5 | 48.6 | 19.7 | 35.2 | |||
Hospital readmissions per 1,000 person-years | 46.3 (22.2–85.1) | 146.0 (85.3–235.0) | 54.2 | (30.3–89.3) | 82.8 (61.8–109.0) |
Values are presented as number only, hazard ratio (95% confidence interval), or percentage only.
BCR, biochemical recurrence.