Figure 3.

(a) The interaction between m⁶A regulators in LUAD. The circle size represented the effect of each regulator on the prognosis, and the range of values calculated by the log-rank test was P < 0.001, P < 0.01, P < 0.05, and P < 0.1, respectively. Purple dots, risk factors of prognosis; green dots, protective factors of prognosis. The lines linking regulators showed their interactions, and thickness showed the correlation strength between regulators. A negative correlation was marked with blue and a positive correlation with red. The regulator of erasers, readers, and writers was marked with red, yellow, and gray, respectively. (b) Difference in the LRPPRC expression between RBM15-mutant and RBM15 types. (c) Difference in the WTAP expression between FMR1-mutant and FMR1 types. (d) Consensus matrices of the cohort for k = 3. (e) Survival analyses for the three m⁶A modification patterns based on 629 patients with LUAD from two cohorts including 145 cases in m⁶A cluster A, 191 cases in m⁶A cluster B, and 283 cases in m⁶A cluster C. Kaplan-Meier curves with log-rank P value 0.045 showed a significant survival difference among three m⁶A modification patterns. The m⁶A cluster B showed significantly better overall survival than the other two m⁶A clusters.