Table 1:

Numbers of organisms, genes, enzymes, and metabolic pathways available in the CAZy, KEGG, and MetaCyc databases

Database	Organisms	Metabolic pathways	Enzymes/Genes
CAZy	Eukaryotes: 344; Bacteria: 20,421; Archaea: 413	NA	GH: 171; GT: 114; PL: 41; CE: 19; AA: 16
KEGG	Eukaryotes: 557; Bacteria: 6,317; Archaea: 344	547	KO groups: 24,402
MetaCyc	Total: 3,295	2,937	13,356

When possible, we detailed the number of organisms for the 3 domains of the tree of life. CAZy includes glycoside hydrolases (GH), glycosyl transferases (GT), carbohydrate esterases (CE), polysaccharide lyases (PL), and auxiliary activities (AA). CAZy: Carbohydrate-Active Enzymes; KEGG: Kyoto Encyclopedia of Genes and Genomes; KO: KEGG Orthology; MetaCyc: metabolic pathways and enzymes; NA: not applicable.