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. 2021 Dec;9(24):1770. doi: 10.21037/atm-21-6134

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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PTEN expression level was correlated with GAS5 expression. (A) qPCR results of the RIPA showed lncRNA GAS5 could compete with PTEN by binding to the Ago2 protein. (B) The binding relationship between PTEN and miR-96-5p was detected by luciferase reporter assay with WT or Mut luciferase reporter plasmids of PTEN. (C) PTEN expression was detected in tissues with and without GAS5 overexpression by immunohistochemical staining (magnification: 100×). PTEN, phosphatase and tensin homolog deleted on chromosome ten; GAS5, growth arrest-specific transcript 5; qPCR, quantitative reverse transcription polymerase chain reaction; RIPA, RNA immunoprecipitation assay; lncRNA, long non-coding RNA. *, P<0.05; **, P<0.01; ***, P<0.001.