Table 1. Characteristics of included trials.

Study	Year	Type of study	Country	Intervention	n	Mean age (years)
Cesne	2021	RCT	France	Trabectedin	52	66.5
				Best supportive care	51	63.7
Chawla	2015	RCT	USA	Trabectedin	83	54
				Doxorubicin	40	54
Demetri	2016	RCT	USA	Trabectedin	345	57
				Dacarbazine	173	56
Hartmann	2020	RCT	Germany	Trofosfamide	80	70
				Doxorubicin	40	70.5
Hensley	2015	RCT	UK	Gemcitabine-docetaxel + trabectedin	53	54.8
				Gemcitabine-docetaxel + placebo	54	56.2
Jones	2019	RCT	UK	Trabectedin + G/D	139	55
				Placebo + G/D	70	54
Martin-Broto	2016	RCT	Spain	Trabectedin + doxorubicin	54	53
				Doxorubicin	59	52
Schöffski	2021	RCT	Belgium	Trabectedin	40	59.5
				Dacarbazine	40	56
Seddon	2017	RCT	UK	Trabectedin	129	56
				Dacarbazine	128	55
Tian	2020	RCT	China	Trabectedin	24	38.58±14.01
				Doxorubicin standard-dose	146	43.30±12.10