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. 2021 Dec;9(24):1799. doi: 10.21037/atm-21-6586

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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BPI-9016M enhanced apoptosis and inhibited radiation-induced DNA damage repair in irradiated Eca109 xenograft tumors. (A) Representative light microscope images of cleaved caspase 3 immunohistochemistry and laser scanning confocal microscopy images of immunofluorescent TUNEL staining (both shown in green) in tumor xenograft sections. *P<0.05 (IR + BPI-9016M compared to IR alone). (B) Western blot analysis of homologous recombination repair-related proteins in xenograft tumor tissues. TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling; IR, irradiation; IHC, immunohistochemical; IF, immunofluorescence; GAPDH, glyceraldehyde-3-phosphate dehydrogenase (was used as a loading control).