Table 3. Hepatocyte transcription factor search.
Landmark factors are highlighted in blue and the bottom row shows Recall@20. Note that KinderMiner and BEST have been censored to articles published through 2009, whereas the other methods have no such censoring, giving them the advantage of access to the landmark papers and more.
| KM-2009 | BEST-2009 | FACTA+ | Polysearch2 |
|---|---|---|---|
| HNF4A | NFKB1 | hepatocyte growth factor | Acetyl-CoA carboxylase biotin
holoenzyme synthetase |
| HNF1A | IRF6 | albumin | HNF-4 |
| HNF1B | TP53 | insulin | ABC16 |
| TCF2 | HNF4A | cytokine | F TCF |
| TCF1 | MYC | c-Met | ABC30 |
| FOXA3 | JUN | collagen | EGF receptor |
| NR1I3 | PPARA | HGF | 5’-AMP-activated protein kinase
catalytic subunit alpha-1 |
| NR0B2 | ESR1 | epidermal growth factor | AQP-7 |
| FOXA2 | HNF1A | VEGF | APRF |
| NR1I2 | STAT3 | cytochrome P450 | FABP-1 |
| NR1H4 | NR3C1 | alanine aminotransferase | ACT2 |
| IPF1 | FOSB | tumor necrosis factor | HAMP |
| FOXA1 | NR1I2 | scatter factor | Apopain |
| FOXF1 | AHR | endoplasmic reticulum | HGF receptor |
| PBX2 | FOS | Met | C8FW |
| NEUROD1 | PPARG | MET | NR1C1 |
| PROX1 | MBD2 | aspartate aminotransferase | CPE-1 |
| ALF | ONECUT1 | ATP | NTCP |
| PAX4 | HNF1B | IL-6 | KLHL-1 |
| FOXO1A | FKHL16 | caspase-3 | SREBF-1 |
| 57% (4/7) | 43% (3/7) | 0% (0/7) | 14% (1/7) |