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. 2021 Sep 27;13(1):34–41. doi: 10.1111/jdi.13669

Figure 3.

Figure 3

Imeglimin‐induced insulin secretion was inhibited by transient receptor potential (TRP) channel blockers and in TRPM2‐knock out mouse. (a) Each batch containing 10 wild‐type mouse islets was incubated for 10 min and insulin secretion was enhanced with 2.8 or 16.6 mM glucose. 100 μM imeglimin or 10 μM 2‐APB was added in 16.6 mM glucose. (b) Each batch containing 10 TRPM2 knockout mouse islets was incubated for 10 min and insulin secretion was enhanced with 2.8 or 16.6 mM glucose. 100 μM Imeglimin was added in 16.6 mM glucose. The number of data points was 5–11. n.s.; not significant. †P < 0.005 vs 16.6 mM glucose, ##P < 0.001 vs 16.6 mM glucose with 100 µM imeglimin by unpaired‐t test.