Table 1.
Subject characteristics and effects of group and (FM) TSPO on clinical parameters.
| FM (n = 83) M (SD, min, max) | HC (n = 43) M (SD, min, max) | GROUP P | TSPO P | GROUP × TSPO P | FM HAB (n = 52) M (SD, min, max) | FM MLAB (n = 31) M (SD, min, max) | FM TSPO P | |
|---|---|---|---|---|---|---|---|---|
| Age | 47.3 (7.8) | 48.1 (7.6) | 0.5545 | NA | NA | 47.3 (7.9) | 47.2 (7.7) | 0.9635 |
| FM duration | 121.3 (87.6, 11, 408) | NA | NA | NA | NA | 131.7 (91.0, 11, 408) | 103.2 (79.6, 11, 288) | 0.1561 |
| Tender points | 16.4 (1.8, 11, 18) | NA | NA | NA | NA | 16.6 (1.9, 11, 18) | 16.2 (1.8, 11, 18) | 0.4629 |
| FIQ | 63.5 (16.4, 13, 95) | NA | NA | NA | NA | 64.9 (14.9, 29, 95) | 61.0 (18.7, 13, 91) | 0.2933 |
| VAS current | 53.5 (22.1, 6, 99) | 2.2 (3.2, 0, 14) | <0.001 | 0.5481 | 0.7202 | 54.5 (22.2, 6, 99) | 51.6 (22.3, 9, 88) | 0.5676 |
| VAS past week | 58.2 (21.5, 15, 100) | 4.3 (5.8, 0, 26) | <0.001 | 0.6438 | 0.4503 | 59.4 (22.8, 15, 100) | 56.1 (19.2, 22, 93) | 0.4955 |
| SF-36BP | 31.0 (14.5, 0, 61) | 89.0 (12.4, 51, 100) | <0.001 | 0.9101 | 0.3446 | 30.2 (14.7, 0, 61) | 32.3 (14.1, 0, 61) | 0.5322 |
| HAD-A | 7.8 (4.3, 0, 21) | 3.1 (2.9, 0, 21) | <0.001 | 0.3464 | 0.9503 | 7.6 (4.1, 0, 19) | 8.3 (4.6, 0, 21) | 0.4742 |
| HAD-D | 7.4 (4.1, 0, 18) | 1.1 (1.5, 0, 5) | <0.001 | 0.2627 | 0.9564 | 7.1 (3.7, 0, 16) | 7.8 (4.7, 1, 18) | 0.4344 |
| PCS | 18.1 (11.0, 0, 48) | 4.7 (7.0, 0, 35) | <0.001 | 0.2698 | 0.5761 | 17.0 (10.8, 0, 48) | 19.8 (11.2, 2, 46) | 0.2757 |
| PPTmean | 151.4 (62.5, 39, 333) | 317.2 (108.1, 77, 633) | <0.001 | 0.4069 | 0.8274 | 147.6 (59.6, 41, 313) | 157.5 (67.5, 39, 333) | 0.4881 |
Reported numbers are P values as well as means (M) with standard deviations (SD), minimum (min) and maximum (max) in parentheses.
FIQ, Fibromyalgia Impact Questionnaire; FM, fibromyalgia; HAB, high affinity binders; HAD-A, Hospital Anxiety and Depression Scale (anxiety score); HAD-D, Hospital Anxiety and Depression Scale (depression score); HC, healthy controls; MLAB, mixed/low affinity binders; NA, not applicable; PCS, Pain Catastrophizing Scale; PPTmean, pressure pain threshold mean; SF-36BP, Short Form-36 bodily pain score; TSPO, translocator protein; VAS, visual analogue scale.