Table 5.

Spearman correlations between the CPM score and glutamate as well as the CPM score and GABA in rACC and thalamus.

	N (rACC/thalamus)	rACC glutamate-CPM				THALAMUS glutamate-CPM				rACC GABA-CPM				THALAMUS GABA-CPM
		Absolute		Relative		Absolute		Relative		Absolute		Relative		Absolute		Relative
		r	P	r	P	r	P	r	P	r	P	r	P	r	P	r	P
Across subjects	106/113	0.1765	0.0703	0.2093	0.0313	0.0704	0.4590	0.1497	0.1134	0.2314	0.0170	0.2413	0.0127	−0.0395	0.6779	0.0082	0.9316
FM	67/72	0.2802	0.0216	0.2754	0.0241	0.0509	0.6713	0.1790	0.1324	0.3365	0.0054	0.3329	0.0059	−0.0833	0.4869	−0.0240	0.8416
HC	39/41	0.0591	0.7208	0.1644	0.3173	0.2298	0.1484	0.1991	0.2120	0.0545	0.7420	0.0289	0.8611	0.2064	0.1954	0.2041	0.2006
HAB	64/64	0.2806	0.0247	0.2255	0.0731	0.0813	0.5230	0.1335	0.2929	0.3143	0.0114	0.2940	0.0184	−0.1434	0.2584	−0.1013	0.4256
MLAB	42/49	0.0560	0.7247	0.1724	0.2751	0.1547	0.2886	0.2716	0.0590	0.1179	0.4570	0.1675	0.2889	0.1901	0.1908	0.2441	0.0910
FM HAB	44/44	0.3951	0.0080	0.3270	0.0303	0.0519	0.7381	0.1841	0.2317	0.4208	0.0045	0.3801	0.0109	−0.1592	0.3019	−0.1134	0.4636
FM MLAB	23/28	0.1206	0.5837	0.2194	0.3146	0.1445	0.4632	0.2841	0.1429	0.1573	0.4736	0.1909	0.3829	0.1768	0.3681	0.2693	0.1658
HC HAB	20/20	0.2165	0.3591	0.1504	0.5269	0.3609	0.1180	0.1805	0.4465	0.0534	0.8231	−0.0715	0.7647	0.1581	0.5055	0.1702	0.4730
HC MLAB	19/21	−0.0667	0.7863	0.0842	0.7318	0.2520	0.2706	0.4156	0.0610	0.1281	0.6013	0.1754	0.4725	0.3177	0.1606	0.3132	0.1669

Correlations, significant at the conventional P < 0.05, are presented in bold.

CPM, conditioned pain modulation; FM, fibromyalgia; GABA, γ-aminobutyric acid; HAB, high affinity binders; HC, healthy controls; MLAB, mixed/low affinity binders; rACC, rostral anterior cingulate cortex; Absolute, absolute compound concentrations; Relative, relative compound concentrations.