. 2021 Dec 15;94(1):336–348. doi: 10.1021/acs.analchem.1c05065

Table 1. Summary of All the Mechanism Illustrated with Relative Limiting Factors, Advantages, and Strategies for ECLM Signal Enhancement^a.

type of mechanism	main limiting factors	advantages	strategies for ECL higher sensitivity
homogeneous	τ of C radical cation and D ox form	• absence of labeling	• confined geometries
			• two materials with different dielectric constant in contact
			• image eloborations with SRRF algorithm
catalytic	τ of D ox form	• absence of labeling	• increase D concentration and acquisition time
catalytic	τ of D ox form	• higher TEL	• different type of C
BPE-ECL	τ of C radical cation and D ox form	• absence of contact between sample and electrode	• combination with magnetic fields
BPE-ECL	τ of C radical cation and D ox form	• absence of contact between sample and electrode	• nanostructures
heterogeneous	τ of C radical cation	• higher spatial and temporal resolution	• different D for optimization of C diffusion toward D
		• simulation of real immunoassay application	• two different mechanisms at short and long distances
			• increase of TEL (chemical lens, conductive materials)
			• electron cathodic treatment

C is for coreactant; D is for dye/luminophore.

Table 1. Summary of All the Mechanism Illustrated with Relative Limiting Factors, Advantages, and Strategies for ECLM Signal Enhancementa.