Table I.

Diagnostic criteria for neurofibromatosis type 1.

Characteristics	Criteria
1. Six or more café-au-lait macules	5 mm in diameter prepubertal 15 mm in diameter postpubertal
2. Two or more neurofibromas or one plexiform neurofibroma	Of any type
3. Freckling	Axillary
	Inguinal (Crowe sign)
4. Optic nerve glioma	-
5. Two or more Lisch nodules (iris hamartomas)	Identified by an ophthalmologist through slit-lamp examination
6. A bone lesion	Sphenoid wing dysplasia
	Typical long bone abnormalities -
	Pseudarthrosis/thinning of cortex
7. A first-degree relative with NF1	Parent
	Sibling
	Offspring