Figure 2.

Characterization of metabolism in porcine ischemic stroke using magnetic resonance spectroscopy (MRS) and tissue samples. Determined with single-voxel ¹H MRS (a). The N-acetylaspartate-to-creatine ratio (NAA/Cr) in the infarct decreased throughout the experiment, while lactate-to-creatine (Lac/Cr) displayed a non-significant increasing tendency. After reperfusion and sacrifice, biopsies showed increased lactate concentration but no changes in normalized lactate dehydrogenase (LDH) or pyruvate dehydrogenase (PDH) activity in the infarcted ipsilateral compared to the contralateral brain (b). Data (n = 6-8) are shown as individual observations with mean ± SD. Tested with linear mixed-effect models.