Table 1.
Description of the study cohort, divided by edema (CED) severity groups.
| Total (n = 924) | CED-3 (n = 101) | CED-2 (n = 72) | CED-1 (n = 287) | CED-0 (n = 277) | |
|---|---|---|---|---|---|
| Age, years, median [IQR] | 69 [59–79] | 71 [58–78.5] | 74 [64–83] | 69 [60–78] | 69 [61–79) |
| Sex, male, n (%) | 518 (56%) | 53 (53%) | 30 (41%) | 159 (55%) | 166 (60%) |
| Race, nonwhite, n (%) | 97 (11%) | 19 (19%) | 8 (11%) | 27 (9%) | 17 (6%) |
| Baseline NIHSS, median [IQR] | 7 [4–14] | 17 [14–21] | 16 [11–19] | 7 [4–12] | 6 [3–11] |
| Acute therapies | |||||
| tPA treatment, n (%) | 614 (66%) | 69 (69%) | 48 (67%) | 197 (69%) | 209 (75%) |
| Thrombectomy, n (%) | 132 (14%) | 25 (25%) | 18 (25%) | 37 (13%) | 41 (15%) |
| Both tPA and thrombectomy, n (%) | 101 (11%) | 19 (19%) | 10 (14%) | 28 (10%) | 32 (12%) |
| Diabetes mellitus, n (%) | 204 (22%) | 24 (24%) | 24 (33%) | 68 (24%) | 58 (21%) |
| Glucose, mg/dl, median [IQR] | 121 [105–146] | 130 [115–158] | 130 [110–170] | 122 [108–147] | 115 [102–133] |
| Systolic BP, mm Hg, median [IQR] | 155 [138–170] | 151 [130–167] | 148 [135–170] | 158 [140–170] | 154 [139–170] |
| Time to baseline CT, h, median [IQR] | 1.9 [1.1–3.5] | 1.5 [1.0–3.7] | 1.9 [1.1–4.9] | 1.8 [1.1–3.3] | 1.9 [1.1–3.6] |
| Baseline ASPECTS, median [IQR] | 10 [9–10] | 8 [6–9] | 9 [6–10] | 9 [8–10] | 10 [10–10] |
| Baseline CSF volume, ml, median [IQR] | 151 [106–202] | 133 [93–171] | 150 [104–199] | 153 [112–205] | 166 [122–213] |
| Baseline hemispheric CSF ratio, median [IQR] | 0.93 [0.87–0.97] | 0.88 [0.81–0.94] | 0.91 [0.83–0.95] | 0.93 [0.88–0.97] | 0.94 [0.90–0.97] |
| 24-hour NIHSS, median [IQR] | 4 [2–11] | 16 [12–22] | 13 [5–18] | 4 [2–9] | 3 [1–6] |
| Time to FU CT, h, media [IQR] | 26 [23–28] | 24 [20–27] | 25 [19–29] | 26 [24–28] | 26 [24–29] |
| TOAST stroke etiology, n (%) | |||||
| Large artery atherosclerosis | 146 (16%) | 18 (18%) | 12 (17%) | 48 (17%) | 48 (17%) |
| Cardioembolism | 363 (39%) | 47 (47%) | 37 (51%) | 130 (45%) | 92 (33%) |
| Small vessel disease | 68 (7%) | 0 | 0 | 14 (5%) | 22 (8%) |
| Other pathogenesis | 37 (4%) | 5 (5%) | 2 (3%) | 12 (4%) | 7 (3%) |
| Undetermined | 310 (34%) | 31 (30%) | 21 (29%) | 83 (29%) | 108 (39%) |
| Peak infarct volume, ml, median [IQR] | 0 [0–28] | 207 [101–294] | 100 [64–138] | 11 [2–29] | 0 [0–0] |
| Peak midline shift, ml, median [IQR] | 0 [0–0] | 5 [3.1–8.9] | 0 [0–0] | 0 [0–0] | 0 [0–0] |
| Inpatient mortality, n (%) | 37 (4%) | 19 (19%) | 6 (8%) | 3 (1%) | 5 (2%) |
ASPECTS: Alberta Stroke Program Early CT Score; BP: blood pressure; FU: follow-up (closest to 24-hours).