Figure 3.
Response of platelets to activation. Following activation, platelets release several molecules from dense granules, exosomes, α-granules, and via synthesis. Dense granules release small molecules. Exosomes release miRs which have functions in coagulation, inflammation, and vasoconstriction. α-granules release proteins which promote coagulation, inflammation, and vasoconstriction. Additionally, α-granules deposit several platelet activation/aggregation receptors on the membrane surface (including glycoprotein (GP)VI, GP1b, P-selectin, platelet-endothelial cell adhesion molecule 1 (PECAM), and integrins).
ADP: adenosine diphosphate; TXA2: thromboxane A2; vWF: von Willebrand factor.