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Vasoconstrictor effects of TRPM8 agonist icilin and vasodilator effects of TRPM8 blocker AMTB on baseline pial arteriolar diameter during normothermia. Icilin (1-10 µM) and AMTB (20 and 50 µM), alone or in combination were topically placed under the cranial window at normothermic conditions, and acute changes in pial arteriolar diameter were recorded. N = 5 pigs, 20 arterioles. Values are means ± SD. *P < 0.05 compared with baseline diameter (Ctr).
