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. 2021 Jun 23;41(11):3069–3084. doi: 10.1177/0271678X211023387

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Figure 1. — (a) Areas characterized by hypoperfusion in chronic low back pain (cLBP) patients compared to healthy controls (HC). The significant hypoperfusion cluster comprises the supplementary motor area, posterior cingulate gyrus, middle frontal gyrus and superior frontal gyrus. Group comparisons of CBF measurements between CLBP patients and healthy controls show an increase in CBF in the hypoperfusion cluster (b) but not in the thalamus (c,d). (e,f,g) Elevated [¹¹C]PBR28 SUV ratios (SUVR, relative to whole brain) were found in cLBP patients in the hypoperfusion cluster and the left thalamus but were not accompanied by increases in CBF. Notations: : significant in voxelwise analyses (cluster-forming threshold of z = 2.3 and cluster size threshold of p = 0.05); ns: not significant; SFG: superior frontal gyrus; MFG: middle frontal gyrus; SMA: supplementary motor area; PCL: paracentral lobule.

Inline graphic — (a) Areas characterized by hypoperfusion in chronic low back pain (cLBP) patients compared to healthy controls (HC). The significant hypoperfusion cluster comprises the supplementary motor area, posterior cingulate gyrus, middle frontal gyrus and superior frontal gyrus. Group comparisons of CBF measurements between CLBP patients and healthy controls show an increase in CBF in the hypoperfusion cluster (b) but not in the thalamus (c,d). (e,f,g) Elevated [¹¹C]PBR28 SUV ratios (SUVR, relative to whole brain) were found in cLBP patients in the hypoperfusion cluster and the left thalamus but were not accompanied by increases in CBF. Notations: : significant in voxelwise analyses (cluster-forming threshold of z = 2.3 and cluster size threshold of p = 0.05); ns: not significant; SFG: superior frontal gyrus; MFG: middle frontal gyrus; SMA: supplementary motor area; PCL: paracentral lobule.