Table 2.
[11C]PBR28 kinetic parameters and outcome measures for baseline vs. hypercapnia sessions together with cerebral blood flow (CBF) measurements in the non-human primates.
| Thalamus |
Prefrontal gray matter |
Occipital cortex |
||||
|---|---|---|---|---|---|---|
| Baseline | Hypercapnia | Baseline | Hypercapnia | Baseline | Hypercapnia | |
| K1 (ml/cm3/min) | 0.13 ± 0.02 | 0.14 ± 0.01 | 0.1 ± 0.02 | 0.1 ± 0.00 | 0.14 ± 0.04 | 0.16 ± 0.03 |
| k2 (min−1) | 0.06 ± 0.02 | 0.09 ± 0.02 | 0.05 ± 0.02 | 0.08 ± 0.02 | 0.07 ± 0.03 | 0.08 ± 0.02 |
| VT | 8.5 ± 2.6 | 6.7 ± 1.9 | 7.4 ± 3.1 | 5.7 ± 1.5 | 7.4 ± 1.3 | 7.1 ± 2.6 |
| DVR | ||||||
| (Ref: whole-brain) | 1.1 ± 0.0 | 1.1 ± 0.1 | 1.0 ± 0.1 | 0.9 ± 0.1 | 1.0 ± 0.2 | 1.1 ± 0.1 |
| (Ref: occipital) | 1.1 ± 0.2 | 1.0 ± 0.2 | 1.0 ± 0.3 | 0.8 ± 0.2 | n/a | n/a |
| SUV[65–90 min] | 1.3 ± 0.2 | 1.1 ± 0.1 | 1.0 ± 0.2 | 0.9 ± 0.2 | 1.2 ± 0.1 | 1.2 ± 0.2 |
| SUVR[65–90 min] (Ref: whole-brain) | 1.2 ± 0.0 | 1.1 ± 0.0 | 0.9 ± 0.1 | 0.9 ± 0.1 | 1.1 ± 0.2 | 1.2 ± 0.2 |
| SUVR[65–90 min] (Ref: occipital) | 1.1 ± 0.2 | 0.9 ± 0.1 | 0.9 ± 0.2 | 0.8 ± 0.2 | n/a | n/a |
| CBF[1–15 min] (ml/100g/min) | 84 ± 8 | 105 ± 19 | 86 ± 4 | 112 ± 16 | 96 ± 30 | 179 ± 34 |
| CBF[65–80 min] (ml/100g/min) | 95 ± 20 | 109 ± 18 | 101 ± 13 | 115 ± 7 | 115 ± 12 | 201 ± 76 |
Note: Average values (with standard deviation) for the plasma-to-tissue rate constant K1, the tissue-to-plasma rate constant k2, volume of distribution (VT), distribution volume ratios (DVR), standard uptake value (SUV for 65–90 min) and corresponding tissue ratios (SUVR), with whole-brain and occipital cortex as a reference (ref), are shown for three regions of interest. Absolute cerebral blood flow (CBF) values obtained with pseudo-continuous arterial spin labeling are shown for the first 15 min and for the 65–80 min periods. Data from a total of 6 experimental sessions obtained in two animals are shown, with baseline and hypercapnia values representing n = 3 sessions each (see Methods for further details).