Table 1. Quality Control Results for [64Cu]CM-1, [64Cu]CM-2, and [64Cu]CM-3a.
| tracer | [64Cu]CM-1 | [64Cu]CM-2 | [64Cu]CM-3c |
|---|---|---|---|
| retention time | 8.18 | 8.36 | 8.28 |
| cLogP | –2.84 | –1.93 | –2.15 |
| radiochemical yield (%) | >99 | >99 | >99 |
| molar activity (GBq μmol–1) | >74 | >74 | >74 |
| radiochemical purity (%)b | >98 | >98 | >98 |
| chelator | DOTA | DOTA | NODAGA |
a
Radiochemical yield (RCY), molar activity, and radiochemical purity of the as-prepared tracer. Data are expressed as mean values (n = 7).
b
The radiochemical purity was determined by HPLC with the conditions as follows: column, YMC-Triat-C18 column (4.6 mm i.d. × 150 mm, 5 μm); solvent gradient, 10–90% acetonitrile (0.1% trifluoroacetic acid (TFA)), 20 min; flow rate, 1 mL/min.
c
[64Cu]CM-3 is an analog of [64Cu]CM-2 while differing by the chelator type. NODAGA: 1,4,7-triazacyclononane,1-glutaric acid-4,7-acetic acid.