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. 2022 Jan 12;20:7. doi: 10.1186/s12964-021-00760-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Glioblastoma-derived EVs elevate the migration of glioblastoma cells. A U87-EVs-treated U87 cells showed higher numbers of migrated cells than DMSO-treated cells in transwell assay. GW4869 largely reduced the number of migrated cells. The addition of U87-EVs to GW4869-treated cells significantly reversed GW4869-induced reduction of migrated cells. B A172-EVs did not alter the numbers of migrated A172 cells in transwell assay. GW4869 largely reduced the number of migrated cells. The addition of A172-EVs to GW4869-treated cells significantly reversed GW4869-induced reduction of migrated cells. C LN229-EVs-treated LN229 cells showed higher numbers of migrated cells than DMSO-treated cells in transwell assay. GW4869 largely reduced the number of migrated cells. The addition of LN229-EVs to GW4869-treated cells significantly reversed GW4869-induced reduction of migrated cells. Results are presented as the mean ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001. Scale bar, 100 μm (A, B, C) and 200 μm (D, E, F)