Table 2.
Antimicrobial activity of sertaconazole nitrate, ciclopirox olamine, and terbinafine according to MLN
| Sertaconazole nitrate | Ciclopirox olamine | Terbinafine | ||||
|---|---|---|---|---|---|---|
| IC50 (µg/ml) | MIC (µg/ml) | IC50 (µg/ml) | MIC (µg/ml) | IC50 (µg/ml) | MIC (µg/ml) | |
| Trichophyton rubrum | 0.0028 ± 0.0003 | 1.3 | 1.02 ± 0.22 | 10.0 | 0.0015 ± 0.0002 | 0.006 |
| Trichophyton soudanense | 0.0014 ± 0.0001 | 3.1 | 1.43 ± 0.78 | 5.0 | 0.0016 ± 0.0005 | 0.015 |
| Trichophyton interdigitale | 0.39 ± 0.01 | 12.5 | 2.62 ± 0.62 | 10.0 | 0.0038 ± 0.0008 | 0.02 |
| Trichophyton indotineae | 0.018 ± 0.003 | 3.8 | 2.09 ± 0.78 | 10.0 | 4.66 ± 0.04 | 20.0 |
| Epidermophyton floccosum | 0.022 ± 0.005 | 1.6 | 1.46 ± 0.22 | 7.5 | 0.0021 ± 0.0001 | 0.02 |
| Scopulariopsis brevicaulis | 0.11 ± 0.03 | 7.5 | 4.85 ± 1.79 | 60.0 | 0.69 ± 0.03 | 40.0 |
| Candida albicans | 0.54 ± 0.12 | 40.0 | 4.01 ± 0.71 | 40.0 | 24.17 ± 2.99 | n.d. |
| Candida parapsilosis | 0.0025 ± 0.0001 | 20.0 | 4.73 ± 0.09 | 80.0 | 0.098 ± 0.002 | 3.8 |
Note: Dose–response curves yielded by MLN are presented in Appendix A.
Abbreviations: IC50, half‐maximal inhibitory concentration; MIC, minimum inhibitory concentration; MLN, microplate laser nephelometry; n.d., not determinable.