Figure 5.
Effect size of eQTL is lower in genes and miRNA that are differentially expressed. The allelic effect size is significantly lower (P < 2.22 × 10−16) in genes that are differentially expressed in both cis- and trans-eQTL. (A) For cis-eQTL, the median variance explained when the transcript is differentially expressed is 0.20 compared to 0.246 when it is not differentially expressed. (B) For trans-eQTL, the median variance explained when the transcript is differentially expressed is 0.127 compared to 0.142 when it is not differentially expressed. (C) The allelic effect size is not significantly different in cis or trans-mirQTL; however, the median of differentially expressed cis-mirQTL is 0.164 compared to 0.215 when not differentially expressed. (D) Similarly, differentially expressed mirQTL in trans had a smaller median than those not differentially expressed at 0.124 and 0.158, respectively.