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. 2021 Jul 14;218(3):iyab068. doi: 10.1093/genetics/iyab068

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© The Author(s) 2021. Published by Oxford University Press on behalf of Genetics Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Comparison of concordant eQTL pairs in mice fed different diets demonstrates similarities despite different environments. Effect size of eQTL observed in both HFCA and HP diets are significantly correlated in both (A) cis-eQTL (r = 0.99) and (B) trans-eQTL (r = 0.99). Allele effects underlying concordant eQTL are highly correlated in both (C) cis-eQTL and (D) trans-eQTL despite different diet perturbations. Black dots represent eQTL with a significant allele-diet interaction (ANOVA, BH-adjusted P < 0.05). Color gradient represents dot density.